Example plot for ROS1 driver gene
The image linked here shows the correlation between low imbalance values and samples that do not contain a fusion (in red). Samples that do contain a fusion (in blue) all contain higher imbalance values.
Zoomed in view:
A 3'/5' Imbalance value of 0.5 or greater indicates the likely presence of a ROS1 fusion.
With a 3'/5' Imbalance value of 0.2, there is no evidence that a ROS1 fusion is present.
The range of 3'/5' Imbalance values between 0.2 and 0.5 is an area of uncertainty where there is some evidence that a fusion may be present. The higher the imbalance value, the more evidence there is that a ROS1 fusion is present.