Copy number estimates are made using a proprietary algorithm.
The VCIB algorithm uses an informatics baseline, which is created using at least 48 diverse samples, to allow assessment of corrected log2ratios of amplicons of identified CNV regions (usually genes) in input sample data. This algorithm is followed by a correction algorithm for the percent tumor cellularity recorded for the sample to give copy number and confidence interval data for the identified CNV regions. The algorithms used to calculate the corrected log2 ratios and the correction for tumor fraction are proprietary.
For details about CNV call results, see the user guide for the assay that you use.